Blackpool have only lost one game in their last six, but a number of draws have prevented the Seasiders from moving out of the playoff places.
For the visiting side, Dave Jones's men still linger in the relegation spots of the table having won just one game this season so far.
The victory came in the form of a 5-2 win over Reading on November 2, but they are likely to remain in the bottom three even if they snatch all three points.
In this fixture last season, neither side was able to break the deadlock in a goalless draw.
Sheffield Wednesday: DDDWLL
Possible starting lineups
Blackpool: Gilks; Basham, Broadfoot, MacKenzie, Blackett; Osbourne, Gosling, Dobbie, Bishop; Ince, Fuller
Sheffield Wednesday: Martinez; Buxton, Llera, Roger Johnson, Mattock; Helan, McPhail, Antonio, Semedo; Wickham, Fryatt
Sports Mole says: 2-0