However, an upturn in form has seen the Terriers climb the table and they could look to finish with a flourish themselves against the Tangerines.
Relegation was confirmed at the start of the month for Blackpool, but their slide into League One has looked inevitable since the start of the season.
On occasions, the Tangerines have even struggled to put out a full matchday squad of senior players while chairman Karl Oyston has continually taken flak for his running of the club.
However, Oyston has risked upsetting the fans further with the removal of the statue of Stan Mortensen outside the ground, where supporters were planning to lay memorabilia to mark the 62 years since his famous FA Cup final hat-trick against Bolton Wanderers.
Four wins at Bloomfield Road all season have helped contribute to Blackpool's descent into English football's third tier – four years after playing in the Premier League.
Despite picking up their four victories on home soil, the Fylde outfit have scored half as many goals (18) in front of their fans as they have on the road (36). Only Sheffield Wednesday have scored fewer at home this season.
Recent form: DDLLLL
Huddersfield have become a difficult side to beat in recent weeks, and have gradually climbed the Championship table.
Now, Powell's side are unbeaten in their last six games, but have drawn their last three, including an enthralling 4-4 draw with playoff-chasing Derby at the John Smith's Stadium a fortnight ago.
A top-half finish is beyond the Terriers now after their 2-2 draw at home to Blackburn Rovers, but Town do have the opportunity to get one over local rivals Leeds United and end the season above the Whites.
However, the Yorkshiremen have been able to score goals, having failed to find the back of the net only once in their previous half a dozen outings.
Huddersfield can also take encouragement from their improving away form, with no defeats in their last four games since a 4-1 reverse at Brentford at the beginning of March.
Recent form: DWWDDD
Darren O'Dea missed last week's defeat at Cardiff City after returning from injury, but Clark has to decide whether to recall the Irishman at the expense of Peter Clarke and Bournemouth loanee Miles Addison.
Blackpool possible starting lineup:
Parish, Maher, Clarke, Addison, Dunne, Cubero Loria, Perkins, O'Hara, Osavi-Samuel, Madine, Cameron
Huddersfield Town possible starting lineup:
Smithies, Smith, Hudson, Wilkinson, Scannell, Coady, Gobern, Butterfield, Lynch, Miller, Wells
Head To Head
Since Blackpool relegation from the Premier League in 2012 they have largely struggled against Huddersfield, having won only one of the last five meetings.
That win came at Bloomfield Road toward the end of last season when an early strike from Ricardo Fuller gave the Tangerines their second win in 21 games after sliding from contention for promotion.
Huddersfield won the reverse fixture 4-2, thanks to a Harry Bunn brace against a Blackpool side still managed by Jose Riga at the point, but who had lost five of their opening seven away games.
Hit play below to see what the Sports Mole Sofa had to say about this encounter:
We say: Blackpool 0-1 Huddersfield
Blackpool might want to end their terrible campaign on a high, but a lack of home victories, or even goals, could count against them on Saturday. Huddersfield are improving of late and we've gone for the Terriers to sneak a win.