They have lost their last two games and suffered a shock 2-0 defeat to Blackpool on Saturday, which means that Brighton & Hove Albion and Blackburn Rovers could still finish above them.
A lack of goals in recent fixtures has also hampered their chances of a return to the Premier League just one season after their relegation.
Meanwhile, Birmingham are facing the prospect of relegation to League One and currently sit in the bottom three.
A defeat would not see them go down, but it would leave them needing to win their last match of the season away at Bolton Wanderers and hope that other results go their way.
They have hit a bad run of form at the worst possible time, with four defeats from their last four games following Saturday's 3-1 reverse against Leeds United.
Possible starting lineups
Birmingham: Randolph, Caddis, Spector, Mullins, Hancox, Adeyemi, Reilly, Huws, Burke, Zigic, Novak
Wigan: Al Habsi, Maloney, Gomez, McManaman, McArthur, Boyce, Espinoza, Beausejour, Perch, Barnett, Waghorn
Sports Mole says: 1-1