"My time at Real Betis has come to an end. Firstly, I want to thank the club and its fans, because for me it's been a real honour to have worked with your club," he posted on his official website.
"Despite having to say goodbye sooner than I'd have liked, I have felt the commitment and passion of the fans. During my time I have had the pleasure of working with some great people. I was surrounded by a group of skilled professionals – people who have worked hard to take the club forward.
"I also cannot forget the players. I wish them all the luck for the future. I am convinced that Real Betis will achieve its goals. Finally, I want to thank the fans again, who are one of the best in Spain."
Former Saudi Arabia coach Gabriel Calderon has taken charge of La Liga's basement club.