Boavista vs. Portimonense (Saturday, 3.30pm)
As Panteras currently occupy the relegation playoff place, two points ahead of the drop zone, but they now sit just one point adrift of automatic safety.
We say: Boavista 2-0 Portimonense
With a tricky away game against Gil Vicente on the final day, Boavista will see this as their best opportunity to pick up a crucial victory to boost their survival bid, and we see them taking all three points on Saturday.
Portimonense seem to have taken their foot off the gas since they quickly climbed away from the drop zone, and they could be outfought by a Boavista side who have far more to play for.
Farense vs. Tondela (Saturday, 3.30pm)
Having failed to win any of their last four games, Os Leoes de Faro find themselves three points adrift of automatic safety and two points behind Boavista in the relegation playoff place, meaning Jorge Costa's side will look to win both of their final two games to stand a real chance of avoiding the drop.
We say: SC Farense 2-1 Tondela
Considering their requirement for a victory and Tondela's poor result last time out, we fancy Farense to seal a crucial win on Saturday.
Costa's men will be desperate to bounce back from the heavy defeat to Porto, and Saturday's home game presents a good opportunity to pick up a result against a side who have little to play for in the league.
Benfica vs. Sporting Lisbon (Saturday, 6.00pm)
Fresh off securing their first Primeira Liga title since 2002 last time out, Sporting Lisbon make the trip to third-placed Benfica on Saturday, as they aim to take another step closer to finishing the season without a league defeat.
With two games left of the campaign, their hosts require two victories to stand a chance of finishing in second spot in the Primeira Liga table, as O Classico rivals Porto sit four points ahead.
We say: Benfica 1-1 Sporting Lisbon
Sporting Lisbon may slightly relax after clinching the title on Tuesday, while Benfica come into this game desperate for a win to potentially keep them in contention for a top-two finish.
However, while the visitors may somewhat take their foot off the gas, they do still have an unbeaten record to keep intact, and we still see them taking a share of the spoils at the Estadio da Luz.
Rio Ave vs. Porto (Saturday, 8.30pm)
The hosts currently sit one point ahead of Boavista in the relegation playoff place and three points above the automatic drop zone, while Porto require a victory to seal second spot and Champions League football for next season.
We say: Rio Ave 0-2 Porto
Although they come into this game with a huge desire for an elusive victory, Rio Ave should fall short against a Porto side full of quality and confidence.
We see last season's champions brushing Cardoso's men aside on Saturday, as they look to confirm second spot.