The two clubs have vastly differing injury lists to contend with for the midweek encounter, and here Sports Mole rounds up all of the latest team news ahead of Thursday's fixture.
Sports Mole's predicted XI: Ter Stegen; Mingueza, Lenglet, Pique; Busquets; Roberto, De Jong, Pedri, Alba; Messi, Griezmann
Out: Antonio Puertas (suspended), Angel Montoro (suspended), Neyder Lozano (head), Luis Milla (hamstring), Domingos Duarte (knee), Carlos Neva (hamstring), Jesus Vallejo (hamstring), Rui Silva (adductor), German Sanchez (shoulder)
Doubtful: Alberto Soro (knee)
Sports Mole's predicted XI: Escandell; Foulquier, Diaz, Perez, Quini; Gonalons, Herrera; Kenedy, Vico, Machis; Suarez