Barca's league form in 2021 has been excellent, winning each of their last seven matches, including a 5-1 victory over Alaves last weekend, which also made it 12 games unbeaten in Spain's top flight.
Koeman's side will enter this weekend's contest off the back of a hugely disappointing result in the Champions League, though, having lost 4-1 to Paris Saint-Germain in the first leg of their last-16 tie.
Barca also have serious work to do if they are to progress to the final of the Copa del Rey, having lost 2-0 to Sevilla in the first leg of their last-four contest on February 10.
Despite their impressive league form, Koeman's side are still third in the table, three points behind second-placed Real Madrid and nine points behind leaders Atletico, meaning that it is going to be incredibly difficult to reclaim the La Liga title, which appears to be staying in Madrid.
Cadiz were excellent in the first half of the season as they stayed in and around the top half, but there is no getting away from the fact that the team are currently going through a difficult spell.
Indeed, Alvaro Cervera's side have picked up just one point from their last five matches, losing their last four to Sevilla, Atletico, Real Madrid and Athletic Bilbao, conceding 15 times in the process.
Cadiz are currently 15th in the table, just three points clear of the relegation zone, meaning that they could soon find themselves pulled into the bottom three if their poor run of form continues.
El Submarino Amarillo have been impressive on their travels this season, though, picking up 14 points from 11 matches, while they were the last team to beat Barca in Spain's top flight, recording a 2-1 victory when the pair locked horns in the reverse game back in December.
Barcelona La Liga form: WWWWWW
Barcelona form (all competitions): WWWLWL
Cadiz La Liga form: WDLLLL
Cadiz form (all competitions): LDLLLL
Barca will again be without the services of Ansu Fati, Philippe Coutinho and Sergi Roberto through injury, while the match is also likely to come too soon for Ronald Araujo, who is battling an ankle issue.
Gerard Pique made his return from injury against PSG and should continue in the heart of the defence, and the bulk of the side that featured in the Champions League is likely to remain in place.
Barcelona possible starting lineup:
Ter Stegen; Dest, Pique, Lenglet, Alba; Pedri, Busquets, De Jong; Trincao, Messi, Griezmann
Cadiz possible starting lineup:
Ledesma; Iza, Alcala, Mauro, Espino; Sanchez, Jonsson, Fali, Perea; Lozano, Negredo
We say: Barcelona 3-0 Cadiz
Barca were disappointing against PSG in the Champions League but ran riot against Alaves in the league last weekend. Cadiz beat the Catalan giants earlier this season but are currently struggling for form, and we are finding it difficult to look past a comfortable home victory for Koeman's side.