The Spanish champions will be confident of coming away with a result, lying 18 points ahead of their struggling opponents ahead of kickoff.
Barca are one of two teams to have won every league fixture so far, the other being Atletico Madrid, who sit one place behind the table toppers on goal difference.
Lionel Messi is expected to feature for the Catalan giants, but may have to settle for a place on the subs' bench following a month-long injury layoff.
Osasuna are languishing in 18th place in the table, but picked up their second win of the season in their last outing, emerging 1-0 victors at Malaga.
A surprise win could move them up into mid-table should other results go their way.
Possible starting lineups
Osasuna: Andres; Damia, Loties, Arribas, Bertran; Lolo, Silva, Sisi, De las Cuevas; Armenteros, Riera
Barca: Valdes; Alves, Pique, Bartra, Adriano; Song, Xavi, Fabregas; Tello, Neymar, Sanchez
Sports Mole says: 1-3