Luis Enrique's men will face a challenge to secure their fifth win of the campaign as Os Celestes are unbeaten in their opening four matches.
Celta have enjoyed an excellent start to the season as they have recorded three wins in their opening four matches, including their 2-1 victory over Sevilla at the weekend.
Strikes from Nolito and Daniel Wass put Eduardo Berizzo's men ahead, and they managed to hold off a comeback in the second half from the home side to secure the win at the Estadio Ramon, despite the sending off Jonny in the 91st minute.
The victory lifted Berizzo's side up into fifth place in the table, as the club have continued on from their solid eighth-place finish of the last campaign. If you include the last five games of last term, Celta are now unbeaten in their last nine games in the league.
Nolito has been impressive at the start of the campaign as he has notched four of his side's 10 goals, while Wass has also chipped in with a couple of strikes. Berizzo will be pleased with his team's attacking prowess at the start of the season.
However, they have looked shaky at the back at times and their 3-3 draw with Las Palmas is proof of that as they allowed a 3-1 lead to slip, while they were also troubled by the Sevilla attack in their 2-1 win at the weekend.
Os Celestes will be tested at the back by Lionel Messi, Neymar and Luis Suarez, and Berizzo will soon find out whether his side have the ability to maintain their solid form at the start of the season.
Recent form: WWDW
Barcelona have begun the defence of their La Liga crown in imperious form by winning all four of their matches at the start of the campaign.
The Catalan club will argue that they have been far from their best in their opening matches as they have only found the net eight times in their first four games, which is below-par by their very high standards. However, their lead at the top of the table is a sign of the quality of the team.
After being shut out in the first half of the match against Levante, Enrique's men showed signs that they were slowly clicking into gear in the final third. Messi notched a brace to take his tally to the season to four strikes, while Neymar scored his second goal of the campaign.
Worryingly for the rest of La Liga, Barcelona managed to secure a comfortable victory with Suarez and Andres Iniesta starting the match on the bench.
Defensively, Enrique will be delighted with how his side have coped with the absence of Gerard Pique, who missed the first four games of the season due to suspension. The team have conceded just two goals and kept two clean sheets in their clashes against Malaga and Bilbao.
Barcelona conceded just 21 goals in the league last term, and Enrique will be determined to match that effort so the return of the 28-year-old will be welcomed as his side have a host of injuries at the back.
Enrique's side also boasted the best away record in the division last term, losing just two of their matches. Celta will provide a stern test of whether they will be able to match that feat this season.
Recent form: WWWW
Recent form (all competitions): DWWWDW
Jonny is suspended for Celta after he was dismissed against Sevilla, and he is likely to be replaced by Carles Planas at left-back.
Pique returns from suspension for Enrique's men and is expected to return straight into the lineup. Javier Mascherano, Marc Bartra and Jeremy Mathieu will battle it out to start alongside the Spaniard, but the Argentine may win the berth.
Suarez started on the bench in the win over Levante, but he will likely be recalled to be part of the three-pronged attack with Messi and Neymar, while Iniesta will also return to the midfield.
Celta possible starting lineup:
Sergio; Mallo, Gomez, Cabral, Planas; Augusto, Pablo, Wass; Orellana, Aspas, Nolito
Barcelona possible starting lineup:
Ter Stegen; Alves, Mascherano, Pique, Adriano; Busquets, Rakitic, Iniesta; Suarez, Messi, Neymar
Head To Head
In the last meeting between the sides, Barcelona secured a 1-0 victory at Balaidos thanks to a 73rd-minute winner from Jeremy Mathieu.
Over the course of history, Barcelona have dominated the contest, securing 18 wins out of a possible 36 matches, while Celta have managed just eight and 10 of the clashes have ended in stalemates.
We say: Celta 2-3 Barcelona
Celta have shown an ability to score goals in the final third, but they could be exposed at the back to the quality of the Barcelona frontline. Enrique's men's experience in defence may just been enough for them to secure a narrow victory, in what could be a high-scoring game.