Ronald Koeman has guided La Blaugrana to victories over Villarreal and Celta Vigo in the early stages of the new campaign, with Barca scoring seven and conceding none in their first two matches.
Barcelona have the chance to put some early pressure on champions Real Madrid - who have registered two wins and a draw thus far - although Sevilla have also won both of their opening matches and will be primed for a hard-fought battle at Camp Nou.
Here, Sports Mole looks at how the Catalan giants could line up for the visit of Sevilla.
While Koeman will be reluctant to make any changes at all to his side following their bright start to the campaign, the Blaugrana manager will be forced into one alteration in the heart of defence.
Clement Lenglet was given his marching orders in the victory over Celta and is suspended for this one, while Samuel Umtiti is expected to remain sidelined with knee problems.
Sergio Roberto's spot at right-back could come under threat following the arrival of Sergino Dest from Ajax, but Roberto capped off an impressive performance against Celta with a late goal, and his spot in the team is safe for now.
Jordi Alba is nailed on to start at left-back amid Junior Firpo's injury worries - the Spaniard missed out against Celta with a hamstring complaint and is also a doubt for this one.
At the other end of the pitch, 17-year-old Ansu Fati has excelled in Barca's opening two matches, registering two goals and an assist against Villarreal before breaking the deadlock in midweek.