Dembele has now featured in his team's last two matches after recovering from a hamstring problem, and the France international is now expected to be considered for a start.
Barcelona are hopeful that Jordi Alba will recover from the muscular problem that he picked up in the 3-1 victory over Villarreal last time out.
As a result, there could be just the one change from the side that started against the Yellow Submarine, with Dembele coming in for Abde Ezzalzouli.
Sergino Dest has been out of favour at Barcelona since Xavi's arrival as head coach, and the defender could again be on the bench alongside Oscar Mingueza, with Ronald Araujo and Eric Garcia set to keep their spots in the back four.
Barcelona possible starting lineup: Ter Stegen; Garcia, Araujo, Pique, Alba; F de Jong, Busquets, Nico; Dembele, Memphis, Gavi