The Catalan giants have won their last three in the league to move to the summit, although they are level on points with second-placed Real Madrid ahead of this weekend's fixtures.
Lionel Messi scored a late winner as Ernesto Valverde's side overcame Atletico Madrid last time out, and the Catalan giants will fancy their chances of picking up a sixth straight win in all competitions this weekend.
Here, Sports Mole looks at how the Spanish champions could line up at Camp Nou.
Barca will again be without the services of injured trio Ousmane Dembele, Jordi Alba and Nelson Semedo, although Gerard Pique is expected to overcome a knock to start.
Pique had to be substituted in the latter stages of the clash with Atletico after picking up a blow to his knee in a challenge with Vitolo, but the centre-back should be available to start on Saturday.body check tags ::