The Uruguay international joined the Catalan side from Liverpool in the summer, but has not yet made his official debut due to a four-month worldwide ban for a biting incident at the World Cup.
That ban will expire at the end of this month, just in time for the La Liga clash with Real Madrid at the Bernabeu.
"You know, I'm the kind of person who believes that things happen for a reason and, out of all 19 teams in the league, it's precisely against Real Madrid at the [Santiago] Bernabeu that I'll make my comeback. There must be a reason," Suarez told Barca Magazine.
"I imagine what it'll be like to pull on the shirt, to be with the rest of the team in the dressing room before the match, getting kitted up to play, and, as chance would have it, in such a stadium. It's a huge coincidence but I'm looking forward to the experience."
Suarez netted twice for Uruguay in an international friendly against Oman on Monday.