Real Valladolid vs. Getafe (Saturday, 1.00pm)
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Saturday's La Liga action begins with Getafe's visit to the Estadio Jose Zorrilla for their crucial clash with 18th-placed Real Valladolid.
Getafe's convincing 3-0 victory over Valencia last weekend went a long way in dispelling rumours that Los Azulones boss Jose Bordalas was destined for the sack. Three points on Saturday could decisively put those rumours to bed.
We say: Real Valladolid 1-2 Getafe
Relegation-threatened Valladolid represent a very different animal in comparison to Valencia and Getafe could have trouble breaking down Sergio's side. Ultimately, we think Los Azulones have what it takes to pick up another significant victory.
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Elche vs. Sevilla (Saturday, 3.15pm)
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Sevilla will hope to overcome their Copa del Rey elimination woes on Saturday when they play Elche in La Liga at the Estadio Martinez Valero.
With just one win in their last 19 league games, the likeliness of 19th-placed Elche playing Segunda Division football next season is becoming more and more probable. Three points this weekend is a must for returning Elche boss Fran Escriba.
We say: Elche 0-1 Sevilla
Sevilla have had a big hiccup this week and it could be difficult for them to dust themselves off, especially when Elche will likely come out fighting for their lives. Regardless of the circumstances, we think Sevilla will come away with the points from this one.
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Cadiz vs. Eibar (Saturday, 5.30pm)
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Saturday afternoon will see a proper relegation six-pointer when Cadiz and Eibar battle it out in La Liga at the Estadio Ramon de Carranza.
Having either lost or drawn against almost all their relegation rivals in recent weeks, this fixture represents Eibar's last real opportunity for a straightforward three points before the tougher fixtures start coming thick and fast.
We say: Cadiz 1-1 Eibar
These are two of La Liga's most out-of-form teams and it is difficult to expect any other outcome than a stalemate. We think these two sides will huff and puff for 90 minutes and eventually settle for a point.
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Osasuna vs. Barcelona (Saturday, 8.00pm)
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Barcelona will be looking to keep the pressure on La Liga leaders Atletico Madrid when they continue their league campaign away to an improving Osasuna on Saturday night.
Ronald Koeman's side are currently second in the table, five points behind Atletico, who have a game in hand, while Osasuna's recent impressive run has seen them rise into 12th position.
We say: Osasuna 0-2 Barcelona
Barca have been impressive in recent matches and will be determined to put another three points on the board this weekend ahead of the second leg of their last-16 Champions League clash with Paris Saint-Germain; Osasuna have shown a lot of improvement, but we are expecting Koeman's side to triumph.
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> How Barcelona could line up against Osasuna