Athletic Bilbao vs. Mallorca (Saturday, 1.00pm)
The Basque club are currently 10th in Spain's top flight, while relegation-threatened Mallorca occupy 18th position, three points from the safety of 17th.
We say: Athletic Bilbao 2-0 Mallorca
Athletic will be keen to return to winning ways following their defeat at Camp Nou, and it is difficult to look past the home side on Saturday taking everything into account. Mallorca have the worst away record in La Liga this term, losing 12 of their 15 matches, and we are predicting another defeat for Moreno's side here.
Celta Vigo vs. Barcelona (Saturday, 4.00pm)
The Spanish champions have fallen behind Real Madrid at the top of the table but will fancy their chances of returning to the summit when they head to Vigo this weekend.
We say: Celta Vigo 0-2 Barcelona
This is potentially a very, very tricky game for Barca, who cannot afford a slip-up ahead of Tuesday's clash with Atletico. The home side will be full of confidence following two strong wins, but we do expect the champions to collect all three points, returning to the top of the table in the process.
Osasuna vs. Leganes (Saturday, 6.30pm)
The visitors are currently 19th in Spain's top flight, four points from the safety of 17th position, while Osasuna occupy 11th spot in the division, 12 points clear of the relegation zone.
We say: Osasuna 1-1 Leganes
Leganes certainly need the points more than Osasuna, but the strugglers have only won one away match this season. Osasuna's home record is actually the fourth worst in the division, though, and we believe that Leganes have enough to claim a point on Saturday night.
Atletico vs. Alaves (Saturday, 9.00pm)
Diego Simeone's side were sixth when they returned to action in the middle of June but have since moved into the top four, while Alaves currently occupy 13th position in Spain's top flight.
We say: Atletico 2-0 Alaves
Atletico have only lost one of their 15 home league matches this season, while Alaves have the second worst away record in the division, picking up just nine points. In truth, we are finding it very tough to predict anything other than a comfortable victory for Simeone's side, who are in excellent form.