Atletico have certainly had their problems domestically during the 2019-20 campaign, but a strong run of form since returning to action on June 14 has seen them solidify a spot in the top four.
As mentioned, Simeone's side entered the lockdown period in sixth position, but they have taken 10 points from their four matches since then to rise into third position in the table.
Sevilla will have the chance to move back above Atletico before this game kicks off, but the capital outfit are currently six points clear of fifth-placed Getafe and therefore in a strong position to claim a top-four spot.
The Red and Whites thumped Osasuna 5-0 on June 17 before recording back-to-back 1-0 successes over Real Valladolid and Levante, and this weekend's clash precedes a huge game away to Barcelona on Tuesday night.
Nine wins, eight draws and 14 defeats - that is how Alaves have performed in Spain's top flight this season, with a total of 35 points leaving them in 13th position in the table.
The Basque side are nine points clear of the bottom three, but they will enter this match off the back of two disappointing defeats to Celta Vigo and Osasuna.
Indeed, Asier Garitano's side conceded six at Celta on June 21 before losing 1-0 at home to Osasuna on Wednesday night, while they have also been beaten by basement side Espanyol since the restart.
It is difficult to imagine Babazorros getting dragged into trouble at this stage, but they will face Atletico and Real Madrid in two of their next four games, which will be slightly concerning for their supporters.
Alaves have lost four of their last five La Liga matches with Atletico, meanwhile, although they did hold the capital giants to a 1-1 draw when the pair locked horns in the reverse match back in October.
Atletico La Liga form: DDDWWW
Atletico form (all competitions): DWDWWW
Alaves La Liga form: DDLWLL
Atletico's squad is in relatively strong shape at the moment, with Sime Vrsaljko their only confirmed absentee for this match. Brazilian defender Felipe remains a doubt with a stomach injury, although it has been suggested that he could overcome the problem in time for this weekend's clash.
Simeone, as expected, shuffled his pack against Levante, meaning that there are expected to be wholesale changes for this game ahead of the clash with Barcelona next week.
Angel Correa, Jose Gimenez, Joao Felix, Alvaro Morata and Kieran Trippier are all likely to return to the starting XI, with Marcos Llorente, Santiago Arigas and Yannick Ferreira Carrasco among those expected to drop out.
Atletico possible starting lineup:
Oblak; Trippier, Savic, Gimenez, Lodi; Koke, Saul, Thomas, Correa; Morata, Felix
Alaves possible starting lineup:
Jimenez; Aguirregabiria, Laguardia, Magallan, Lopez; Sainz, Pina, Pons, Mendez; Perez, Joselu
We say: Atletico 2-0 Alaves
Atletico have only lost one of their 15 home league matches this season, while Alaves have the second worst away record in the division, picking up just nine points. In truth, we are finding it very tough to predict anything other than a comfortable victory for Simeone's side, who are in excellent form.