The Spaniards currently have a two-point lead over second-placed Milan at the top of the table following a 1-1 draw between the teams at the San Siro two weeks ago.
Barca are in scintillating form at the moment, with 13 wins and four draws from 17 matches this season.
In contrast, Milan are in the middle of a difficult campaign after picking up just five victories from 16 games in all competitions.
Possible starting lineups
Barca: Valdes; Alves, Pique, Mascherano, Montoya; Sanchez, Xavi, Busquets, Iniesta, Neymar; Messi
Milan: Gabriel; Abate, Zaccardo, Zapata, Constant; Montolivo, De Jong, Muntari, Saponara, Kaka; Balotelli
Sports Mole says: 2-0