Martino knows Atletico boss Diego Simeone from their playing days, while the two managers have overseen a number of feisty clashes this season.
However, Martino has said that the clash this evening is purely about advancing into the semi-finals of the competition.
"No, the prize is to get into the semi-finals. Each one belongs to a group who work hard and do their best. One will end up very pleased, the other very sad," he told AS.
The two sides are currently level at 1-1 from the first leg.