The striker joined the Gunners on deadline day from Manchester United for £16m and he will lead the home side's attack, with Alexis Sanchez and Mesut Ozil offering the support from advanced midfield positions.
Meanwhile, Frank Lampard will make his first appearance for the visitors following his loan switch from New York City in the summer.
Arsenal: Szczesny; Debuchy, Mertesacker, Koscielny, Monreal; Flamini, Wilshere; Ramsey, Alexis, Ozil; Welbeck
Man City: Hart; Zabaleta, Kompany, Demichelis, Clichy; Fernandinho, Lampard; Navas, Silva, Milner; Aguero
You can follow Sports Mole's live text commentary of the clash in North London here.