The Spaniard has been included in the midfield alongside Aaron Ramsey and Tomas Rosicky. Elsewhere, Lukas Podolski will continue as a lone centre-forward, with Theo Walcott given a role wide on the right.
Meanwhile, Steve Harper, who will retire after this match, has been handed a start in goal for the hosting Magpies.
Newcastle: Harper; Debuchy, S.Taylor, Coloccini, Yanga-Mbiwa; Tiote, Cabaye, Gutierrez, Ben Arfa; Cisse, Gouffran
Arsenal: Szczesny; Sagna, Mertesacker, Koscielny, Gibbs; Arteta, Ramsey, Rosicky; Cazorla, Walcott; Podolski