The Gunners are aiming to pick up a third win in a row in all competitions to continue their good run of form heading into the final stretch of the season.
Saka and Smith Rowe passed fitness tests to start Thursday's 4-0 win over Slavia Prague, with the young pair linking up brilliantly alongside Nicolas Pepe in attacking midfield.
However, with this London derby coming just three days on from the trip to the Czech capital, both players could be left out of the side this weekend.
Martin Odegaard is another who can play in that central attacking midfield position, but he has missed three games through injury and is not likely to start this one.
How Arsenal could line up against Fulham: Leno; Bellerin, Holding, Mari, Xhaka; Partey, Elneny; Willian, Ceballos, Martinelli; Lacazette
Watch the Sports Mole Football Shorts prediction for this game below: