Sam Allardyce could start Matt Jarvis on Saturday after the former Wolverhampton Wanderers player found the net in the Hammers' 2-1 win over Queens Park Rangers on Monday evening, while Andy Carroll could also return to the starting XI.
Meanwhile, Wenger could keep Gervinho in the starting lineup, sitting just in front of Lukas Podolski, Santi Cazorla and Alex Oxlade-Chamberlain, which could mean another start on the bench for Olivier Giroud.
West Ham: LWDDW
West Ham: Jaaskelainen; Demel, Reid, Collins, O'Brien; Noble, Diame; Vaz Te, Nolan, Jarvis; Carroll
Arsenal: Mannone; Jenkinson, Koscielny, Vermaelen, Gibbs; Ramsey, Arteta; Oxlade-Chamberlain, Cazorla, Podolski, Gervinho
Sports Mole says: 1-2