The Eagles are yet to appoint a new manager following the departure of Holloway, who admitted that he had tried to make too many changes ahead of the club's return to the top flight.
Going through such a transition is not ideal for Palace, who will have to face in-form Arsenal after securing just one victory out of eight league fixtures in the campaign.
In the five times that these two sides have played against each other, Arsenal have come out on top three times, while Palace have not grabbed one victory over the North London outfit.
Palace are likely to stick with Marouane Chamakh and Dwight Gayle up front, while Jack Wilshere could miss out for the Gunners after suffering a knock in their 2-1 defeat to Borussia Dortmund in the Champions League on Tuesday.
Crystal Palace: WLLLLL
Possible starting lineups
Crystal Palace: Speroni; Ward, Mariappa, Delaney, Moxey; Jedinak, Dikgacoi, Campana, O'Keefe; Chamakh, Gayle
Arsenal: Szczesny; Sagna, Mertesacker, Koscielny, Gibbs; Arteta, Ramsey, Ozil; Cazorla, Flamini; Giroud
Sports Mole says: 0-2