Manchester City and Chelsea don't play until Monday, so the Gunners can establish a two-point advantage over Manuel Pellegrini's side with a win over Palace.
Manager Tony Pulis has guided Palace to four wins in their last eight fixtures, but he will be aware that his side will be up against it in North London.
Crystal Palace: DWLWLW
Possible starting lineups
Arsenal: Szczesny; Sagna, Gibbs, Mertesacker, Koscielny; Arteta, Gnabry, Oxlade-Chamberlain, Ozil, Cazorla; Giroud
Crystal Palace: Speroni; Mariappa, Ward, Gabbidon, Delaney; Moxey, Bolasie, Jedinak, Puncheon; Jerome, Chamakh
Sports Mole says: 3-0