Arsenal vs. Burnley (Sunday, 2.00pm)
The Gunners currently find themselves sixth in the rankings - two points worse off than fourth-placed West Ham United - while Sean Dyche's men remain rooted to the bottom of the pile.
We say: Arsenal 2-0 Burnley
Whether Burnley's COVID-hit contingent are ready to return or not, their lack of recent action could work against them, especially versus an Arsenal side more determined than ever to pick up their first win of 2022.
Dyche will certainly instruct his side to expose Arsenal's midfield frailties while the hosts' naughty step remains well-occupied, but the Gunners' bright, youthful attacking forces should propel their side to a much-needed three points.
Crystal Palace vs. Liverpool (Sunday, 2.00pm)
Meanwhile, the hosts are returning to action nine days after playing out an enthralling 1-1 draw with Brighton & Hove Albion in the M23 derby.
We say: Crystal Palace 1-3 Liverpool
The travelling fans cannot expect to witness their side storm to another seven-goal romping at Selhurst Park, and Palace need no lessons in finding the back of the net in front of the home faithful.
However, Liverpool have now proved that their goalscoring touch without Salah and Mane remains well and truly alive, so we are backing the Reds to prevail with minimal difficulty.
Leicester vs. Brighton (Sunday, 2.00pm)
Brighton & Hove Albion will be looking to stretch their unbeaten run in the Premier League to six matches when they travel to the King Power Stadium to face Leicester City on Sunday afternoon.
The Seagulls are currently ninth in the table, picking up 29 points from their 21 league games this term, while Leicester are 10th, four points behind their opponents here with two matches in hand.
We say: Leicester City 1-1 Brighton & Hove Albion
Brighton are a team to be taken extremely seriously in the Premier League this season, and we find it difficult to back the Seagulls to lose on their travels considering their form. Leicester will again be missing a number of important players, meanwhile, so we have had to settle on a low-scoring draw here.
Chelsea vs. Spurs (Sunday, 4.30pm)
The Blues are currently third in the table, eight points clear of fifth-placed Tottenham, but Antonio Conte's side have four games in hand on the hosts, having seen a number of recent matches postponed.
We say: Chelsea 1-1 Tottenham Hotspur
This is a very difficult match to call, with Chelsea struggling to win Premier League games in recent weeks. Tottenham are a much-improved outfit under Conte's management, meanwhile, and we believe that the visitors will have enough quality to secure a share of the spoils at Stamford Bridge this weekend.