Victory over the Toffees would enhance Arsenal's chances of qualifying for the Champions League next season.
With that in mind, Wilshere believes that the fans can play a part in helping the players record a positive result at the Emirates Stadium.
"Big game tonight at Emirates against Everton! Big support again from the fans #Arsenal #COYG," he wrote on Twitter.
Reports have suggested that Wilshere will be rested for the encounter following his recent return from an ankle injury.