Tottenham goalkeeper Hugo Lloris was sent back onto the pitch against Everton after taking a blow to the head, and Wenger said that this exceptional circumstance should be recognised by the rulebook.
"I am for a change of rule on that because imagine that England leads 1-0 in a World Cup final after 80 minutes, that you have made your three changes and exactly the same situation happens to your goalkeeper," Sky Sports News quotes Wenger as saying.
"Would you then decide to take the goalkeeper off and put the right-back in goal and play with 10 men? Or would you be in favour of leaving your goalkeeper on?
"I believe in this exceptional circumstance and down to the fact that a goalkeeper is a special position - you would allow the goalkeeper to come off and replace him with the other goalkeeper, even if you have changed your three players."
Lloris was given the all-clear after a scan earlier in the week.