The Spaniard scored for Arsenal in the reverse fixture earlier in the season, which the Gunners lost 2-1.
The 28-year-old told the club's website: "Above all we need to keep the ball. If we have the ball, we're definitely going to hurt them. We're a team that keeps possession well and knows how to hurt the opposition.
"If we don't, it'll be the reverse. They'll cause us problems because they have a lot of quality and when given space they can threaten us. Keeping the ball is the key. We need to force them back and not give them time on the ball as they have players that can make a difference.
"We always look forward to the big games. They're coming here having won the league and we hope that they'll be more relaxed than if they had to win the league on our pitch, but it's going to be a very difficult game."
Arsenal are currently third in the Premier League table.