The Gunners were beaten 3-1 by the Premier League champions on Monday night and quickly face the most difficult assignment in English football again with a spot in the quarter-finals up for grabs.
Arsenal had been unbeaten this season prior to Monday's meeting, though, and beat Liverpool in the Community Shield in August in addition to a league victory over them in July.
Here, Sports Mole looks at how Mikel Arteta could set his side up for the contest.
Arsenal could have Cedric Soares and Sokratis back available for this match, helping to ease their defensive injury crisis with Shkodran Mustafi and Pablo Mari both still sidelined.
Both Cedric and Sokratis narrowly missed out on a place in the matchday squad for Monday, but Arteta could view the EFL Cup as a good opportunity for them to get much-needed minutes under their belts.
It is likely to be a very different XI to the one which started the last game at Anfield, with Gabriel Magalhaes - a surprise omission in the league meeting as David Luiz replaced him - among those pushing for a recall.
Arsenal's victory over Leicester City in the previous round saw the likes of Sead Kolasinac, Nicolas Pepe, Eddie Nketiah, Joe Willock and Reiss Nelson all come into the starting lineup, and they will hope to have done enough to be named in the XI again this time around.