The Gunners have defeated Sheffield United and Slavia Prague in their last two games without conceding, while Fulham have lost each of their last four matches.
Here, Sports Mole rounds up all of the latest team news for the two clubs ahead of this clash at the Emirates Stadium.
Sports Mole's predicted XI: Leno; Bellerin, Holding, Mari, Xhaka; Partey, Elneny; Willian, Ceballos, Martinelli; Lacazette
Sports Mole's predicted XI: Areola; Aina, Andersen, Adarabioyo; Tete, Lemina, Reed, Robinson; Cordova-Reid, Loftus-Cheek; Mitrovic
Watch the Sports Mole Football Shorts prediction for this game below: