Trailing 3-1 from the first leg in Piraeus, the Greek giants remain without two centre-backs in Ruben Semedo and Avraam Papadopoulos, while Ousseynou Ba's involvement is uncertain due to back trouble.
Former Arsenal man Sokratis is fit and raring to go for his return to the Emirates, though, and he could be partnered with makeshift centre-back Yann M'Vila once again as Martins works around a trio of absences.
Full-backs Kenny Lala and Oleg Reabciuk were both benched for the weekend's victory over Larissa but should be reinstated to the first XI here, while Mady Camara and Andreas Bouchalakis are set to form Martins's double pivot if M'Vila is forced to deputise in defence once more.
The visiting manager shuffled the pack considerably for Sunday's Super League battle with the second leg in mind, and further alterations up top should see Mathieu Valbuena, Bruma and Georgios Masouras all reinstated to the starting lineup.
Youssef El Arabi knows all about scoring crucial goals on the Emirates turf, and the 34-year-old netted for the 22nd time this season off the bench against Larissa last time out, so he is expected to spearhead the attack over Ahmed Hassan.
Olympiacos possible starting lineup:
Sa; Lala, Sokratis, M'Vila, Reabciuk; Camara, Bouchalakis; Bruma, Valbuena, Masouras; El Arabi