Teenage starlet Bukayo Saka lasted just 45 minutes of Sunday's North London derby after sustaining a hamstring problem, and with the England international facing a race to be fit for this game, Nicolas Pepe could be brought back into the attack.
Arteta revealed that Pierre-Emerick Aubameyang was dropped from the first XI against Tottenham Hotspur due to disciplinary reasons, but the forward is in contention to return up top here as he looks to erase the memories of his horror miss in last year's defeat to the Greek giants.
Willian could come into Arteta's thinking for a start out wide, but Martin Odegaard and Emile Smith Rowe continue to prove their importance to this Arsenal side and are unlikely to be dropped for this pivotal clash.
There could be at least one alteration in midfield, though, as Granit Xhaka and Thomas Partey have played a lot of football recently and at least one of them could be granted a rest, allowing Dani Ceballos the chance to rectify his mistake in Piraeus.
Mohamed Elneny is another option in the middle of the park after his screamer in the first leg, while Hector Bellerin was dropped for the weekend's victory against Tottenham but should displace Cedric Soares at right-back.
Gabriel Magalhaes has starred for Arsenal over the past week, but he may be rested for the second leg ahead of the weekend's meeting with West Ham United, which would allow Pablo Mari the chance to reignite his strong run of form.
Arsenal possible starting lineup:
Leno; Bellerin, Luiz, Mari, Tierney; Xhaka, Ceballos; Pepe, Odegaard, Smith Rowe; Aubameyang