The contest will go ahead despite escalating tensions in Ukraine, although it has been moved from Poltava to Kiev after martial law was declared in the area.
Arsenal must put the off-field issues to one side as they bid to remain unbeaten, knowing that they only need to match or better Sporting Lisbon's result to clinch first place.
Here, Sports Mole looks at how Unai Emery could set his side up for the contest.
Emery has used the Europa League to shuffle his pack so far this season, and that is only going to increase with Arsenal now guaranteed a place in the last 32.
Youngsters such as Emile Smith Rowe, Eddie Nketiah and Julio Pleguezuelo could be called into the side, while more experienced campaigners such as Petr Cech and Stephan Lichtsteiner are expected to be handed rare starts.
Lichtsteiner should overcome a thigh injury to feature, while Laurent Koscielny could also have a part to play for the first time since May as he steps up his recovery from an Achilles injury.
Fellow injury doubt Alexandre Lacazette will not be risked, but the lesser-spotted Carl Jenkinson is another player who might be afforded a chance to impress.