The Rossoneri have performed well since returning to action last month and are close to securing a European spot, while Bologna are winless in three and have little left to play for.
Those have not exactly been easy fixtures, either, having defeated top-two sides Juventus and Lazio in quick succession, as well as beating Roma and drawing with Napoli.
Milan had to ride their luck at times but that is now three home wins in a row and a place in the top seven now seems a formality, the Rossoneri holding a six-point lead on Sassuolo with five games to go.
However, one of those games happens to be against Sassuolo, who have themselves looked impressive of late, so Pioli will know the importance of staying on track with another victory this weekend.
Bologna head into the match on the back of successive draws over Parma and Napoli, with Musa Barrow netting late on to snatch a point in the latter of those fixtures.
The Rossoblu are exactly midway in the table, 10 points behind Milan in the final Europa League spot and 13 points above the relegation zone.
Anything less than victory on Saturday will kill off their slim European hopes, then, but Sinisa Mihajlovic will be pleased enough with his campaign regardless.
Bologna have a pretty decent away record, too, losing just two of their last nine matches, with victories over Roma, Napoli and Inter Milan during that run.
Milan have won three in a row at San Siro, though, and have won seven of their last eight meetings with Bologna, drawing the other.
AC Milan's Serie A form: WDWWDW
Bologna's Serie A form: WDWLDD
Lucas Paqueta pulled out of Milan's squad with a knee injury in midweek and is considered doubtful for this match.
Elsewhere, Riccardo Orsolini is pushing for a recall after being brought off the bench against Napoli.
AC Milan possible starting lineup:
Donnarumma; Conti, Kjaer, Romagnoli, Hernandez; Biglia, Kessie; Leao, Bonaventura, Calhanoglu; Rebic
Bologna possible starting lineup:
Skorupski; Mbaye, Danilo, Tomiyasu, Krejci; Medel, Dominguez; Olsen, Soriano, Barrow; Palacio
We say: AC Milan 2-1 Bologna
Milan have stepped up a gear since the restart and Pioli's job now appears to be safe. The hosts will be eager to keep building momentum with victory and, despite Bologna's impressive results away at big clubs, we are backing them to prevail this weekend.