The 21-year-old, who recently returned from a three-month lay-off through injury, is poised to partner Mario Balotelli in attack as the Rossoneri seek the point necessary to secure their progression to the last-16 stage.
The former Barcelona youth spent a loan spell with Milan and will partner Davey Klaassen - who hit a hat-trick in the 4-0 win over NAC Breda on Saturday - as the focal point of attack.
AC Milan: Abbiati; de Sciglio, Zapata, Constant, Bonera; Muntari, Montolivo, de Jong, Kaka; Balotelli, El Shaarawy
Ajax: Cillessen; van Rhijn, Moisander, Blind, Denswil; Poulsen, Schone, Serero, Fisher; Bojan, Klaassen
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