The Italians have had an indifferent start to the new Serie A season, having lost two of their opening three matches.
Former Barcelona striker Bojan has also been tipped to make his full debut for the Rossoneri.
Meanwhile, visiting Anderlecht will have to make do without last year's leading goalscorer Matias Suarez, who recently underwent knee surgery.
The last two times that these two sides have met at this level (1993 and 2006), Milan went on to win the competition.
Milan: Abbiati; Abate, Bonera, Acerbi, Antonini; De Jong; Ambrosini, Boateng, Montolivo; Pazzini, Bojan
Anderlecht: Proto; Odoi, Wasilewski, Deschacht, Safari; Gillet, Biglia, Kanu, Yakovenko; Mbokani, De Sutter
Sports Mole says: 2-1