In May, just one point separated McDonnell and Kameda, but on this occasion, the margin of victory was much clearer as the Doncaster man continued to establish himself in the United States.
Despite McDonnell prevailing in Texas, it was Kameda who started the sharper of the two, frequently catching the British fighter with left hooks that looked like they could wear him down later in the contest.
However, McDonnell was superb behind his jab, and even when Kameda got through, he was responding with flurries of his own and by the championship rounds, his Japanese opponent was becoming increasingly desperate.
In the final three minutes, McDonnell capped off a career-best performance with a knockdown, with a short right and a slippery canvas contributing to Kameda hitting the floor.
He made it to the final bell, but it was McDonnell who scored verdicts of 116-111, 115-112 and 117-110 respectively to extend his professional record to 27 victories from 30 outings.