Wade, who missed the previous four games with a knee injury, scored eight points in a 24-minute appearance at the AmericanAirlines Arena after being introduced to the action towards the end of the first quarter.
"I've only had one practice in a while," the 32-year-old told reporters. "Team was in a good groove. I wanted to work my way into my rhythm.
"I didn't expect [to miss four games] but I did what was right and I'm playing now. Hopefully I can get into a rhythm a little bit."
Wade has missed 13 games for the Heat this season.