Wasps currently sit one from bottom in the table and will be hoping to build on their sole victory of the season against London Irish.
Dai Young has named an experienced Wasps side, featuring James Haskell and Steven Jones, with youngster Elliot Daily only named on the bench.
The Wasps side will also be boosted by the return of skipper Hugo Southwell from a broken finger.
After securing their first victory of the season last weekend, also against London Irish, Worcester will be looking to build up a winning run.
Warriors head coach Richard Hill has made only one change to his side which beat London Irish, with Jon Clarke handed his first start after coming off the bench to score last week.
Clarke could face a busy afternoon, lining up against the dangerous Wasps wingers Tom Varndell and Christian Wade.
Speaking ahead of the match, Wasps coach Dai Young said: "We had a decent win there in our last match and we know how important home form is so this is an important game. Worcester will come here with lots of confidence having scored some very good tries in their last few games and they always bring with them a strong set piece and defensive game."
London Wasps: Southwell, Varndell, Masi, Bell, Wade, Jones, Simpson, McIntyre, Lindsay. Taulafo, Palmer, Wentzel, Launchbury, Haskell, Vunipola
Worcester Warriors: Pennell, Clarke, Grove, Matavesi, Lemi, Goode, Arr, Mullan, Lutui, Andress, Percival, Schofield, Jones, Betty, Kvesic
Sports Mole says: Wasps