The Premier League outfit head into the clash on the back of a 3-2 win over Manchester United in the league but the North London outfit could only muster a goalless draw against Lazio in their last European outing.
The Greens have failed to open the deadlock in three of their last European games, while Spurs have only conceded one goal in their previous four away matches.
Andre Villas-Boas is likely to field a relatively strong side for tonight's clash with Jermain Defoe and Clint Dempsey expected to pose an attacking threat. However, it is likely to be too soon for striker Emmanuel Adebayor, who is slowly recovering from a hamstring strain.
Panathinaikos: Karnezis; Vyntra, Boumsong, Velaquez, Spyropoulos; Christodoulopoulos, Mavrias, Vitolo; Zeca Sissoko; Fornaroli
Tottenham: Lloris; Walker, Caulker, Naughton, Vertonghen; Sandro, Dembele; Lennon, Dempsey, Bale; Defoe
Sports Mole says: 0-2