Sir Alex Ferguson's side have won every league fixture since their opening-day defeat to Everton, while new Tottenham boss Andre Villas-Boas has had an inconsistent start, winning just two of his first five games of the campaign.
The former Premier League champions could boast a side with Wayne Rooney at the forefront following the striker's return to action in United's 2-1 win over Newcastle United in the League Cup last night.
Manchester United: WWWWW
Manchester United: Lindegaard; Rafael, Ferdinand, Evans, Evra; Carrick, Giggs; Valencia, Kagawa; Rooney, Van Persie
Tottenham: Friedel; Walker, Gallas, Vertonghen, Lennon; Bale, Sandro, Dembele, Sigurdsson; Dempsey, Defoe
Sports Mole says: 2-1