Hugo Lloris, Michael Dawson and Tom Huddlestone come into the side that beat Manchester United 3-2 last Sunday.
Tottenham Hotspur boss Andre Villas-Boas has made three changes to the side that beat Manchester United 3-2 at Old Trafford last Sunday.
Hugo Lloris comes into the team in place of Brad Freidel, while Michael Dawson has been preferred to William Gallas in the centre of defence.
Jan Vertonghen starts as left-back for Spurs, who are looking for their first win of the Europa League campaign.
Tom Huddlestone starts in midfield, as Sandro drops to the bench. Jermain Defoe starts as the lone sriker.
Former Arsenal youngster Quincy Owusu-Abeyie starts for the home side.
Panathinaikos: Karnezis; Seitaridis, Triantafyllopoulos, Pinto, Vyntra; Christodoulopoulos, Zeca, Vitolo, Marinos; Owusu-Abeyie, Toche
Spurs: Lloris; Walker, Dawson, Caulker, Vertonghen; Dembele, Huddlestone; Lennon, Dempsey, Bale; Defoe
Team News: Dawson starts for much-changed Spurs >