The R's are hoping to get back to winning ways following their first defeat of the season at Burnley last weekend.
Despite that setback, a victory at the DW Stadium will see Redknapp's side move back into second place in the Championship table.
"We knew it was going to be tough at Burnley, like we know it's going to be another tough game tonight," Redknapp told the club's official website. "We've got to go there and see if we can come away with a positive result.
"The fans have enjoyed seeing us win at Bolton, Leeds and Yeovil and we really appreciate the support they're giving us. They've been fantastic for us and we want to give them another good result tonight."
Wigan start the match in 15th place in the table, eight points off the playoff places.