A 1-0 victory over Oldham Athletic on Saturday left Port Vale eighth in the League One table, five points off the playoff positions.
That result also made it six games without defeat in front of their own fans for Port Vale, and they will rely on home advantage in their attempt to pull off a shock result this weekend.
They will have to do it without Carl Dickinson, however, as the defender is suspended for Saturday's match.
While Port Vale are chasing the playoffs in League One, Brighton are doing the same a division above and sit just two points behind sixth-placed Reading in the Championship.
That ended a four-match unbeaten streak for Oscar Garcia's side, while it was just their third away defeat since the opening day of the season.
The Championship outfit have struggled for goals recently, only scoring more than two in a game once since December 7, and managing just four in their last five matches.
They will be without Craig Mackail-Smith once again as the striker continues his journey back to fitness following a lengthy absence through injury.
Port Vale: WLDLWW
Possible starting lineups
Port Vale: Neal; Chilvers, Robertson, Grimmer, Davis; Griffith, Loft, Cuvelier, Williamson; Myrie-Williams, Pope
Brighton: Kuszczak; Greer, Upson, Ward, Bruno; Ince, Lopez, Orlandi, Andrews, Forster-Caskey; Ulloa
Sports Mole says: 1-1