The League One side upset the odds when they beat Liverpool 3-2 at Boundary Park in the fourth round and will be looking for another Merseyside scalp on Saturday evening.
Oldham caretaker manager Tony Philliskirk could be without Matt Smith, who scored twice against Liverpool, as he is struggling to overcome a shoulder injury. Robbie Simpson is also a doubt for the tie.
Toffees boss David Moyes will be without Tony Hibbert and Seamus Coleman through injury. Victor Anichebe, who limped out of Everton's defeat at Manchester United last week, may lose his place in the starting XI to Nikica Jelavic.
Oldham Athletic: DLLLLW
Possible starting lineups
Oldham Athletic: Bouzanis; Brown, Byrne, Mvoto, Grounds; Croft, Furman, Wesolowski, Simpson; Baxter, Barnard
Everton: Howard; Neville, Distin, Jagielka, Baines; Osman, Gibson, Naismith, Fellaini, Pienaar; Jelavic
Sports Mole says: 0-2