The Red Devils are on course to snatch the title from their fierce rivals Manchester City, who clinched the trophy in the dying seconds of last year's campaign, as they currently sit nine points clear at the top of the table.
Everton managed to secure a dramatic 4-4 draw at United's home ground last time around and a similar result will help their chances of qualifying for the Champions League as they are just one point adrift of fourth-placed Tottenham Hotspur.
United boss Sir Alex Ferguson revealed today that Ashley Young is fit for the contest, so he could slot into the starting lineup, while Victor Anichebe may be selected by Toffees boss David Moyes over Nikica Jelavic.
Manchester United: WWDWW
Possible starting lineups
Manchester United: De Gea; Rafael, Ferdinand, Evans, Evra; Valencia, Cleverley, Giggs, Young; Rooney; Van Persie
Everton: Howard; Jagielka, Heitinga, Distin, Baines; Mirallas, Gibson, Osman, Pienaar; Fellaini; Anichebe
Sports Mole says: 2-1