Georginio Wijnaldum is one of two new signings to make their full league debuts for Newcastle United in their Premier League opener against Southampton.
Chancel Mbemba is also handed his first start by Steve McClaren, who takes charge of the Magpies for the first time.
However, Aleksandar Mitrovic must wait to make his Premier League debut, with the ex-Anderlecht forward named as one of United's substitutes.
Meanwhile, Southampton manager Ronald Koeman will miss the game at St James' Park after rupturing his Achilles tendon.
Saints are without Ryan Bertrand, Florin Gardos, Gaston Ramirez and Fraser Forster. Shane Long has recovered from illness to make the bench, but Jordy Clasie joins the lengthening list of injuries.
Newcastle United: Krul; Janmaat, Mbemba, Coloccini, Haidara; Anita, Colback, Sissoko, Wijnaldum, Obertan; Cisse
Subs: De Jong, Aarons, Perez, Tiote, Darlow, Taylor, Mitrovic
Southampton: Stekelenburg; Soares, Fonte, Yoshida, Targett; Davis, Wanyama, Tadic, Mane; Rodriguez, Pelle
Subs: Long, Martina, Ward-Prowse, Reed, Juanmi, Gazzaniga, Caulker
