The current English champions face a tough home fixture against the Reds, who managed to secure a 2-2 draw against City at the start of the campaign at Anfield in August.
City slipped in their quest to retain the Premier League title in midweek when they were held to a goalless draw by Queens Park Rangers, while Brendan Rodgers's side sit in seventh in the table following a 2-2 draw with Arsenal on Wednesday.
City will line up without captain Vincent Kompany as he continues to struggle with a calf injury, while the North-West side will compete in their first official game without striker Mario Balotelli, who finalised a move to AC Milan yesterday.
Man City: DWWWW
Possible starting lineups
Man City: Hart; Zabaleta, Nastasic, Lescott, Clichy; Barry, Garcia; Milner, Silva, Aguero; Dzeko
Liverpool: Reina; Wisdom, Skrtel, Agger, Johnson; Henderson, Lucas; Suarez, Gerrard, Sterling; Sturridge
Sports Mole says: 1-1