The Spanish left-back, whose last start came against Queens Park Rangers in December, has fully recovered from his hamstring injury and replaces Andre Wisdom, as manager Brendan Rodgers makes just one change from the side that drew 2-2 at Arsenal in midweek.
Man City: Hart; Zabaleta, Nastasic, Lescott, Clichy; Milner, Garcia, Barry, Silva; Dzeko, Aguero
Subs: Pantilimon, Maicon, Kolarov, Nasri, Sinclair, Rodwell, Tevez
Liverpool: Reina, Johnson, Enrique, Agger, Carragher, Lucas, Gerrard, Henderson, Downing, Suarez, Sturridge
Subs: Jones, Wisdom, Skrtel, Allen, Shelvey, Sterling, Borini