Villas-Boas, who was a coach under Mourinho at Porto, Chelsea and Inter Milan, has led his Spurs side to eight wins from nine matches in all competitions this season.
They warmed up for this weekend's match by securing a comfortable 4-0 victory over Aston Villa in the third round of the League Cup on Tuesday evening.
Chelsea also earned a cup victory in midweek when they beat Swindon Town 2-0 at the County Ground.
Possible starting lineups
Spurs: Lloris; Walker, Dawson, Vertonghen, Naughton; Dembele, Paulinho; Townsend, Eriksen, Sigurdsson; Soldado
Chelsea: Cech; Ivanovic, Cahill, Terry, Cole; Ramires, Mikel; Schurrle, Oscar, Hazard; Eto'o
Sports Mole says: 1-1